Component-Based Design and Assembly of Heuristic Multiple Sequence Alignment Algorithms
نویسندگان
چکیده
منابع مشابه
A Fast Template Based Heuristic For Global Multiple Sequence Alignment
Advances in bio-technology have made available massive amounts of functional, structural and genomic data for many biological sequences. This increased availability of heterogeneous biological data has resulted in biological applications where a multiple sequence alignment (msa) is required for aligning similar features, where a feature is described in structural, functional or evolutionary ter...
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An ever-increasing number of biological modeling methods depend on the assembly of an accurate multiple sequence alignment (MSA). These include phylogenetic trees, profiles, and structure prediction. Assembling a suitable MSA is not, however, a trivial task, and none of the existing methods have yet managed to deliver biologically perfect MSAs. Many of the algorithms published these last years ...
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The multiple alignment of the sequences of DNA and proteins is applicable to various important elds in molecular biology. Although the approach based on Dynamic Programming is well-known for this problem, it requires enormous time and space to obtain the optimal alignment. On the other hand, this problem corresponds to the shortest path problem and the A algorithm, which can e ciently nd the sh...
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Proteins or genes that have similar sequences are likely to perform the same function. One of the most widely used techniques for sequence comparison is sequence alignment. Sequence alignment allows mismatches and insertion/deletion, which represents biological mutations. Sequence alignment is usually performed only on two sequences. Multiple sequence alignment, is a natural extension of two-se...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2020
ISSN: 1664-8021
DOI: 10.3389/fgene.2020.00105